RESOURCES

THE EVOLUTION OF CELL AND GENE THERAPY PROCESSING TOOLS

Borrowed Tools from Other Industries

Prior to the invention of gene therapy research, the removal, storage and reinsertion of human cell tissue was limited to blood. The logistical and technical challenges were minimal. However, scientists quickly discovered that maintaining the integrity and transparency of autologous and allogeneic cells throughout extraction, storage, transportation, delivery and administration presented a myriad of logistical challenges exceeding the capabilities of the current machines and materials available. If gene therapy was to succeed, a new generation of machines, processes and storage materials were needed. 

  • The first attempts at cell/gene therapies
    • Why were these therapies developed
    • What tools were used to create the therapy
    • What hurdles were identified during manufacturing
      • Cryopreservation
      • Fluid management
      • Cell growth – hpl product and its effect on cell growth

Testing